Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor
نویسندگان
چکیده
منابع مشابه
Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling.
Over the last two decades, the incidence of obesity and associated metabolic syndrome diseases has risen dramatically, becoming a global health crisis. Increased caloric intake and decreased physical activity are believed to represent the root causes of this dramatic rise. However, recent findings highlight the possible involvement of environmental obesogens, xenobiotic chemicals that can disru...
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Organotin compounds such as triphenyltin (TPT) and tributyltin (TBT) act as endocrine disruptors through the peroxisome proliferator-activated receptor γ (PPARγ) signaling pathway. We recently found that TPT is a particularly strong agonist of PPARγ. To elucidate the mechanism underlying organotin-dependent PPARγ activation, we here analyzed the interactions of PPARγ ligand-binding domain (LBD)...
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The third countrywide survey on imposex and organotin contamination in the rock shell was conducted in 93 locations along the Japan coast between September 1996 and January 1999. The percentage occurrence of imposex was still high in 86 locations whereas no or rare instances of imposex were found in the remaining seven locations. Severe imposex symptoms were observed in the rock shell populatio...
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An unintended consequence of our chemical innovations is the introduction of trace chemicals into our environment that are not necessarily directly toxic, but can impact nature. Mutations in animals/people can happen naturally, but perhaps in many cases human chemical ingenuity is to blame. Our motivations as chemists are honorable, and we have generated pesticides that help us to grow more foo...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2008
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.33.269